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The amino acid that operates at most inhibitory synapses in the brain is ________.


A) acetylcholine
B) endorphin
C) nitric oxide
D) gamma-aminobutyric acid (GABA)

E) A) and C)
F) B) and D)

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The heart rate of a vertebrate will decrease in response to the arrival of ________.


A) acetylcholine
B) endorphin
C) nitric oxide
D) gamma-aminobutyric acid (GABA)

E) None of the above
F) A) and B)

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Why are action potentials usually conducted in one direction?


A) The nodes of Ranvier conduct potentials in one direction.
B) The brief refractory period prevents reopening of voltage-gated sodium channels.
C) The axon hillock has a higher membrane potential than the terminals of the axon.
D) Voltage-gated channels for both Na⁺ and K⁺ open in only one direction.

E) C) and D)
F) A) and D)

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Of those listed, which event occurs first following a depolarizing stimulus applied to the presynaptic membrane of an axon terminal?


A) Voltage-gated calcium channels in the membrane open.
B) Synaptic vesicles fuse with the membrane.
C) The postsynaptic cell produces an action potential.
D) Ligand-gated channels open, allowing neurotransmitters to enter the synaptic cleft.

E) C) and D)
F) A) and C)

Correct Answer

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Why do Na⁺ ions enter the cell when voltage-gated Na⁺ channels are opened in neurons?


A) because the Na⁺ concentration is much lower outside the cell than it is inside
B) because the Na⁺ ions are actively transported by the sodium-potassium pump into the cell
C) because the Na⁺ concentration is much higher outside the cell than it is inside, and the Na⁺ ions are attracted to the negatively charged interior
D) because the Na⁺ concentration is much higher outside the cell than it is inside, and the Na⁺ ions are actively transported by the sodium-potassium pump into the cell

E) A) and B)
F) B) and C)

Correct Answer

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A neurophysiologist is investigating nerve reflexes in two different animals: a crab and a fish. Action potentials are found to pass more rapidly along the fish's neurons. What is the most likely explanation?


A) The fish's axons are smaller in diameter; small axons transmit action potentials faster than large axons do.
B) Unlike the crab, the fish's axons are wrapped in myelin.
C) There are more ion channels in the axons of the crab compared with fish axons.
D) Unlike the crab, the fish's axons are wrapped in myelin, and the fish's axons are smaller in diameter; small axons transmit action potentials faster than large axons do.

E) None of the above
F) All of the above

Correct Answer

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A chemical that affects neuronal function but is not stored in presynaptic vesicles is ________.


A) acetylcholine
B) epinephrine
C) nitric oxide
D) gamma-aminobutyric acid (GABA)

E) A) and D)
F) B) and C)

Correct Answer

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What happens when a resting neuron's membrane depolarizes?


A) There is a net diffusion of Na⁺ out of the cell.
B) The equilibrium potential for K⁺ (EK) becomes more positive.
C) The neuron's membrane voltage becomes more positive.
D) The cell's inside is more negative than the outside.

E) A) and B)
F) B) and C)

Correct Answer

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